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This rapid induction of T-bet at low IFN-γ levels emphasized the role of IFN-γ in biologically relevant conditions. Moreover, this suggested that activation of Stat1 is necessary, but not sufficient, for T-bet induction by IFN-γ. Figure 4. T-bet mRNA is induced specifically by IFN-γ …

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Apr 16, 2002 · T-bet-deficient B lymphocytes demonstrate impaired production of IgG2a, IgG2b, and IgG3 and, most strikingly, are unable to generate germ-line or postswitch IgG2a transcripts in response to IFN-gamma. Conversely, enforced expression of T-bet initiates IgG2a switching in cell lines and primary cells. This function contributes critically to the ...

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